drug-discovery
De novo protein design: how a computer invents a molecule that sticks Lesson
De novo protein design means inventing a protein that does not exist in nature and that binds a chosen target, by predicting how a chain of amino acids will fold and then searching for a chain that folds into a shape which fits. It works because structure prediction got good enough to grade designs before anyone builds them.
Claude designed protein binders against 14 of 15 targets and two labs built every one of them News
Anthropic said on August 18 that Claude designed minibinders against 15 protein targets and succeeded on 14, with hit rates of 26.7 and 22.6 percent against the 10 to 15 percent typical of protein design campaigns, validated by two independent contract labs.
Isomorphic Labs Unveils a Drug-Design AI That Beats Physics at Predicting How Drugs Bind News
Isomorphic Labs, the DeepMind drug-discovery spinout, unveiled a Drug Design Engine that surpasses even physics-based methods at predicting binding strength and recomputed a cereblon drug pocket that took 15 years to find in the lab.
Chai Discovery design suite Tool
An interactive design canvas for biologics rather than a prediction tool: choose an antibody format, choose or infer the target structure, pick the epitope, target a specific antigen state, and specify chemical modifications. Commercial access with limited academic availability.